- API
Any substance that is represented for use in a drug and that, when used in the manufacturing, processing, or packaging ...
- Active Ingredient
Any component that is intended to furnish pharmacological activity or other direct effect in the diagnosis, cure, ...
- CAS No.
Unique number assigned to a specific chemical (identified by its chemical name) by the American Chemical Society and ...
Celastrol
Catalog No. | PI0034 |
---|---|
CAS No. | 34157-83-0 |
Molecular Formula | C29H38O4 |
Molecular Weight | 450.61 |
Purity | 98% HPLC |
Package | 25 kg/drum |
Botanical Source | Tripterygium wilfordii |
Appearance | Red powder |
Storage | Stored in cool and dry places, protected from direct sunlight and heat. |
Shelf Life | 2 years |
Note: This celastrol can also be used as reference standards. You can find it under the category of Reference Substance at Herbalext.com. |
Safety Tips of Celastrol
Handling of celastrol should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.
Related Products
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Catalog No.: HE0218
Specification: 0.4%-0.8% Valeric Acid HPLC
Package: 25 kg/drum
Botanical Source: Valerian Root
Related Applications
Antineoplastic
Each year, more and more people are getting cancer, especially lung and liver cancer. However, there are not enough good anti-cancer drugs. Fortunately, many herbal extracts have good antineoplastic activity. A plant-based diet can help shield you from cancer because plants are rich in anti-inflammatory and antioxidant substances that help us withstand exposure to ultraviolet radiation, air pollution and other noxious substances.
Related Researches
- 1. Celastrol attenuates adipokine resistin-associated matrix interaction and migration of vascular smooth muscle cells.
Kang SW, et al. J Cell Biochem 2013 Feb;114(2):398-408.
- 2. Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders.
Johnson TA, et al. Phytomedicine 2013 Jan 15;20(2):143-7.
- 3. Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway.
Kim JH, et al. Cell Signal 2013 Apr;25(4):805-13.
- 4. The Extent of Neurodegeneration and Neuroprotection in Two Chemical In Vitro Models Related to Parkinson's Disease is Critically Dependent on Cell Culture Conditions.
Jantas D, et al. Neurotox Res 2013 Jan 10.
- 5. Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
Ding QH, et al. Eur J Pharmacol 2013 Feb 8;708(1-3):1-7.
- 6. Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells.
Davis AL, et al. Int J Mol Sci 2013 Feb 19;14(2):4185-202.
- 7. Proteasome inhibition protects human peripheral blood mononuclear cells from radiation-induced oxidative stress.
Stankova K, et al. Int J Radiat Biol 2013 Apr 16.
- 8. Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2).
Tan KW, et al. Food Chem 2013 Jun 15;138(4):2267-74.
- 9. Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer.
Shao L, et al. PLoS One 2013;8(3):e58391.
- 10. Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90.
Matokanovic M, et al. Eur J Pharm Sci 2013 Apr 10.