- API
Any substance that is represented for use in a drug and that, when used in the manufacturing, processing, or packaging ...
- Active Ingredient
Any component that is intended to furnish pharmacological activity or other direct effect in the diagnosis, cure, ...
- CAS No.
Unique number assigned to a specific chemical (identified by its chemical name) by the American Chemical Society and ...
Podophyllotoxin
Catalog No. | PI0111 |
---|---|
CAS No. | 518-28-5 |
Molecular Formula | C22H22O8 |
Molecular Weight | 414.41 |
Purity | 98% HPLC |
Package | 10 kg;25 kg/drum |
Botanical Source | rhizomes of American Mayapple (Podophyllum peltatum) or of Podophyllum hexandrum Royle (Berberidaceae) |
Appearance | Powder |
Shelf Life | 2 years |
Note: This podophyllotoxin can also be used as reference standards. You can find it under the category of Reference Substance at Herbalext.com. |
Safety Tips of Podophyllotoxin
Handling of podophyllotoxin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.
Related Applications
Antineoplastic
Each year, more and more people are getting cancer, especially lung and liver cancer. However, there are not enough good anti-cancer drugs. Fortunately, many herbal extracts have good antineoplastic activity. A plant-based diet can help shield you from cancer because plants are rich in anti-inflammatory and antioxidant substances that help us withstand exposure to ultraviolet radiation, air pollution and other noxious substances.
Related Researches
- 1. Next generation sequencing in predicting gene function in podophyllotoxin biosynthesis.
Marques JV, et al. J Biol Chem 2013 Jan 4;288(1):466-79.
- 2. Synthesis and quantitative structure-activity relationship (QSAR) study of novel 4-acyloxypodophyllotoxin derivatives modified in the A and C rings as insecticidal agents.
He S, et al. J Agric Food Chem 2013 Jan 23;61(3):618-25.
- 3. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells.
Wang B, et al. Am J Chin Med 2013;41(1):163-75.
- 4. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives.
Guerrero E, et al. Pharm Biol 2013 May;51(5):566-72.
- 5. Novel linear and step-gradient counter-current chromatography for bio-guided isolation and purification of cytotoxic podophyllotoxins from Dysosma versipellis (Hance).
Yang Z, et al. J Sep Sci 2013 Mar;36(6):1022-8.
- 6. Induction of apoptosis through caspase-independent or caspase-9-dependent pathway in mouse and human osteosarcoma cells by a new nitroxyl spin-labeled derivative of podophyllotoxin.
Yang TM, et al. Apoptosis 2013 Jun;18(6):727-38.
- 7. Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives.
Li WQ, et al. Bioorg Med Chem 2013 Apr 15;21(8):2363-9.
- 8. Enantioselective Formal Synthesis of (-)-Podophyllotoxin from (2S,3R)-3-Arylaziridine-2-carboxylate.
Takahashi M, et al. J Org Chem 2013 Apr 5;78(7):3250-61.
- 9. Antifeedant activity of spin-labeled derivatives of deoxypodophyllotoxin against Brontispa longissima larvae.
Feng G, et al. Nat Prod Commun 2013 Feb;8(2):199-202.
- 10. [Carboxyl nanodiamond as intracellular transporters of anticancer drug--podophyllotoxin].
Sun TL, et al. Yao Xue Xue Bao 2013 Jan;48(1):149-54. Chinese.