- API
Any substance that is represented for use in a drug and that, when used in the manufacturing, processing, or packaging ...
- Active Ingredient
Any component that is intended to furnish pharmacological activity or other direct effect in the diagnosis, cure, ...
- CAS No.
Unique number assigned to a specific chemical (identified by its chemical name) by the American Chemical Society and ...
4-Hydroxyisoleucine
Catalog No. | PI0003 |
---|---|
CAS No. | 55399-93-4 |
Molecular Formula | C6H13NO3 |
Molecular Weight | 147.17 |
Purity | 20%, 98% HPLC |
Package | 25 kg/drum |
Botanical Source | Trigonella foenum-graecum L |
Appearance | White powder |
Storage | Stored in cool and dry places, protected from direct sunlight and heat. |
Shelf Life | 2 years |
Note: This 4-hydroxyisoleucine can also be used as reference standards. You can find it under the category of Reference Substance at Herbalext.com. |
Safety Tips of 4-Hydroxyisoleucine
Handling of 4-hydroxyisoleucine should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.
Related Products
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Catalog No.: HE0086
Specification: 2% Phosphatide HPLC 10% Anthraquinone HPLC
Package: 25 kg/drum
Botanical Source: Fo-Ti Root
Related Applications
Glucose Regulation
Diabetes is an important human ailment afflicting many from various walks of life in different countries. It is proving to be a major health problem, especially in the urban areas. Hundreds of thousands of people suffer from diabetes, a condition that destroys cells in the pancreas and leaves the body unable to regulate blood sugar levels. Many plant extract can help to regulate blood glucose and lipids.Anti-hyperlipidemic
In some people, cholesterol levels in blood become too high. This is called high cholesterol or hyperlipidemia. High levels of LDL cholesterol (Low-density lipoprotein cholesterol) are considered a major risk factor for cardiovascular disease such as heart attack and stroke. There are several classes of hypolipidemic drugs. Many herbal extracts can be of great benefit to adjusting the lipid levels of blood.
Related Researches
- 1. A novel l-isoleucine-4'-dioxygenase and l-isoleucine dihydroxylation cascade in Pantoea ananatis.
Smirnov SV, et al. Microbiologyopen 2013 Apr 2.
- 2. Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats.
Haeri MR, et al. Phytomedicine 2012 May 15;19(7):571-4.
- 3. A novel family of bacterial dioxygenases that catalyse the hydroxylation of free L-amino acids.
Smirnov SV, et al. FEMS Microbiol Lett 2012 Jun;331(2):97-104.
- 4. 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway.
Jaiswal N, et al. Eur J Nutr 2012 Oct;51(7):893-8.
- 5. Expression, purification, crystallization and preliminary X-ray analysis of 4-hydroxy-3-methyl-2-keto-pentanoate aldolase (asHPAL) from Arthrobacter simplex strain AKU 626.
Guo L, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Aug;68(Pt 8):958-61.
- 6. Biochemical monitoring in fenugreek to develop functional food and medicinal plant variants.
Thomas JE, et al. N Biotechnol 2011 Feb 28;28(2):110-7.
- 7. A novel L-isoleucine metabolism in Bacillus thuringiensis generating (2S,3R,4S)-4-hydroxyisoleucine, a potential insulinotropic and anti-obesity amino acid.
Ogawa J, et al. Appl Microbiol Biotechnol 2011 Mar;89(6):1929-38.
- 8. Characterization of Bacillus thuringiensis L-isoleucine dioxygenase for production of useful amino acids.
Hibi M, et al. Appl Environ Microbiol 2011 Oct;77(19):6926-30.
- 9. Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice.
Singh AB, et al. Nat Prod Res 2010 Feb;24(3):258-65.
- 10. An Organocatalyzed enantioselective synthesis of (2S,3R,4S)-4-hydroxyisoleucine and its stereoisomers.
Kumaraswamy G, et al. J Org Chem 2010 Apr 16;75(8):2745-7.